Recombinant Human TIMP-1
Catalog Number : 410-01
TIMP1 is an extracellular inhibitor of MMPs (see above) including MMP1, 2, 3, 7, 8, 9, 10, 11, 12, 13, and 16. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP1 can also act through an MMP-independent mechanism to promote erythropoiesis by stimulating proliferation and differentiation of erythroid progenitors. Recombinant human TIMP-1 is a 20.6 kDa protein containing 184 amino acid residues.
Above 95% as determined by SDS-PAGE Analysis.
TIMP1 activity was measured by its ability to inhibit human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-1 concentration of approximately 0.5 μg/ml, when using an MMP-1
CTCVPPHPQ TAFCNSDLV IRAKFVGTP EVNQTTLYQ RYEIKMTKM YKGFQALGD AADIRFVYT PAMESVCGY FHRSHNRSE EFLIAGKLQ DGLLHITTC SFVAPWNSL SLAQRRGFT KTYTVGCEE CTVFPCLSI PCKLQSGTH CLWTDQLLQ GSEKGFQSR HLACLPREP GLCTWQSLR SQIA
|Research Interest:||Stem Cell Research, Angiogenesis, Inflammation, Proliferation and Cell Cycle|
|Protein Cross Reactivity:||NULL|