Recombinant Human Tigar
Catalog Number : 150-14
TIGAR is a p53-inducible enzyme that catalyzes the hydrolysis of fructose-2-6 bisphosphate (F-2-6-BP) to fructose-6-phosphate and inorganic phosphate. F-2-6-BP is a powerful activator of 6-phosphofructose-1 kinase, the rate limiting enzyme of glycolysis. By lowering the intracellular level of F-2-6-BP, TIGAR expression leads to increased glucose processing via the pentose phosphate pathway, the major cellular source for NADPH. Recombinant human TIGAR expressed in E. coli is a 29.9 kDa protein containing 269 amino-acid residues.
Above 95% as determined by SDS-PAGE Analysis.
Data not available.
ARFALTVVR HGETRFNKE KIIQGQGVD EPLSETGFK QAAAAGIFL NNVKFTHAF SSDLMRTKQ TMHGILERS KFCKDMTVK YDSRLRERK YGVVEGKAL SELRAMAKA AREECPVFT PPGGETLDQ VKMRGIDFF EFLCQLILK EADQKEQFS QGSPSNCLE TSLAEIFPL GKNHSSKVN SDSGIPGLA ASVLVVSHG AYMRSLFDY FLTDLKCSL PATLSRSEL MSVTPNTGM SLFIINFEE GREVKPTVQ CICMNLQDH LNGLTETR
|Research Interest:||Apoptosis, Cancer, Proliferation and Cell Cycle|
|Protein Cross Reactivity:||NULL|