Recombinant Human Nanog
Catalog Number : 120-21
description
Nanog is a regulatory protein that is associated with undifferentiated pluripotent cells. The expression of Nanog, which is suppressed in all adult tissues, is restricted to embryonic stem cells and to certain pluripotent cancer cells. Decreased expression of Nanog is strongly correlated with cell differentiation. Nanog, most likely, acts as an intracellular regulator, which maintains pluripotency and self renewal via a STAT3 independent pathway. Recombinant human Nanog is a 34.5 kDa protein, which is synthesized as a 304 amino acid polypeptide lacking a signal sequence for secretion.
Additional Information
Source: | E. Coli |
Purity: | Above 95% as determined by SDS-PAGE Analysis. |
Cross Reactivity: | NULL |
Biological Activity | Data Not Available. |
AA Sequence | SVDPACPQS LPCFEASDC KESSPMPVI CGPEENYPS LQMSSAEMP HTETVSPLP SSMDLLIQD SPDSSTSPK GKQPTSAEN SVAKKEDKV PVKKQKTRT VFSSTQLCV LNDRFQRQK YLSLQQMQE LSNILNLSY KQVKTWFQN QRMKSKRWQ KNNWPKNSN GVTQKASAP TYPSLYSSY HQGCLVNPT GNLPMWSNQ TWNNSTWSN QTQNIQSWS NHSWNTQTW CTQSWNNQA WNSPFYNCG EESLQSCMQ FQPNSPASD LEAALEAAG EGLNVIQQT TRYFSTPQT MDLFLNYSM NMQPEDV |
| Research Interest: | Stem Cell Research |
|---|---|
| Cell Type: | Stem Cells |
| Application: | FA |
| Protein Cross Reactivity: | NULL |