Recombinant Human Fetuin A/AHSG
Catalog Number : 140-13
Fetuin A/AHSG is a human plasma glycoprotein belonging to the Cystatin family of proteases inhibitors. It is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. Fetuin A/AHSG is a major serum protein component that exerts various calcium dependent physiological activities, and can mediate growth signaling in certain tumor cells. It also can act as a natural antagonist against specific TGF-β and BMP signaling proteins, Recombinant human Fetuin-A is a heterodimeric protein containing a 282 amino acid A chain and a 27 amino acid B chain. Due to glycosylation, recombinant Fetuin-A migrates at an apparent molecular weight of 45 – 55 kDa by SDS-PAGE run under non-reducing conditions.
Above 98% as determined by SDS-PAGE Analysis.
Determined by its ability to inhibit Cathespin V cleavage of a fluorogenic peptide substrate Z-LR-AMC (RLUs). The expected IC50 is ≤ 100nM.
A-Chai n:APH GPGLIYRQP NCDDPETEE AALVAIDYI NQNLPWGYK HTLNQIDEV KVWPQQPSG ELFEIEIDT LETTCHVLD PTPVARCSV RQLKEHAVE GDCDFQLLK LDGKFSVVY AKCDSSPDS AEDVRKVCQ DCPLLAPLN DTRVVHAAK AALAAFNAQ NNGSNFQLE EISRAQLVP LPPSTYVEF TVSGTDCVA KEATEAAKC NLLAEKQYG FCKATLSEK LGGAEVAVT CTVFQTQPV TSQPQPEGA NEAVPTPVV DPDAPPSPP LGAPGLPPA GSPPDSHVL
B- Chain:TVVQPSVG AAAGPVVPP CPGRIRHFK V
|Research Interest:||Cancer, Bone Biology, Proliferation and Cell Cycle|
|Cell Type:||Macrophage / Monocyte|
|Protein Cross Reactivity:||NULL|