Recombinant Human Apo-SAA
Catalog Number : 300-13
Human apo-SAA is a 104 amino acid polypeptide that circulates primarily in association with high-density lipoproteins (HDL). The level of apo-SAA, normally 1-5 μg/ml in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apo-lipoprotein. The human SAA gene codes for a 122 amino acid polypeptide, which contains an 18 amino acid N-terminal signal sequence. Recombinant Apo-SAA is a consensus SAA molecule corresponding to human apo-SAA1α except for the presence of an N-terminal methionine and substitution of asparagine for aspartic acid at position 60 and arginine for histidine at position 71(the latter two substituted residues are present in apo-SAA2β).
Above 98% as determined by SDS-PAGE Analysis.
Bacteria, Hamster, Mouse, Rabbit, Rat
Tested by its ability to down-regulate lipid biosynthesis in aortic smooth muscle cells. The effective concentration was found to be 4 μM.*
* Schreiber, BM. et al. Biochem J. 1999 Nov 15; 344 Pt 1:7-13
MRSFFSFLG EAFDGARDM WRAYSDMRE ANYIGSDKY FHARGNYDA AKRGPGGVW AAEAISNAR ENIQRFFGR GAEDSLADQ AANEWGRSG KDPNHFRPA GLPEKY
|Research Interest:||Inflammation, Metabolic Regulation and Diabetes|
|Protein Cross Reactivity:||Bacteria, Hamster, Mouse, Rabbit, Rat|