Recombinant Human β-NGF

Grouped product items
Size Price Qty
20µg
$80.00
100µg
$195.00
250µg
$385.00
500µg
$660.00
1mg
$1,100.00
Catalog Number : 450-01

description

β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
Chicken, Hamster, Mouse, Rat
Biological Activity
Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg
AA Sequence
SSSHPIFHR GEFSVCDSV SVWVGDKTT ATDIKGKEV MVLGEVNIN NSVFKQYFF ETKCRDPNP VDSGCRGID SKHWNSYCT TTHTFVKAL TMDGKQAAW RFIRIDTAC VCVLSRKAV RRA
Research Interest: Innate Immunity, Stem Cell Research, Angiogenesis, Neurosciences, Inflammation
Cell Type: B Cells, Neurons
Application: FA
Protein Cross Reactivity: Chicken, Hamster, Mouse, Rat
© BioGems International, Inc. All rights reserved.