Animal-Free Recombinant Human β-NGF
β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity. Manufactured using all non-animal reagents.
Above 98% as determined by SDS-PAGE Analysis.
Chicken, Hamster, Mouse, Rat
Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg
SSSHPIFHR GEFSVCDSV SVWVGDKTT ATDIKGKEV MVLGEVNIN NSVFKQYFF ETKCRDPNP VDSGCRGID SKHWNSYCT TTHTFVKAL TMDGKQAAW RFIRIDTAC VCVLSRKAV RRA
|Research Interest:||Innate Immunity, Stem Cell Research, Angiogenesis, Neurosciences, Inflammation|
|Cell Type:||B Cells, Neurons|
|Protein Cross Reactivity:||Chicken, Hamster, Mouse, Rat|