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Recombinant Human CDNF



Catalog Number : 450-05

Description

CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and its structural homolog MANF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human CDNF is an 18.5 kDa protein consisting of 162 amino acids including 8 cysteine residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/ml.
 
AA Sequence
MQEAGGRPG ADCEVCKEF LNRFYKSLI DRGVNFSLD TIEKELISF CLDTKGKEN RLCYYLGAT KDAATKILS EVTRPMSVH MPAMKICEK LKKLDSQIC ELKYEKTLD LASVDLRKM RVAELKQIL HSWGEECRA CAEKTDYVN LIQELAPKY AATHPKTEL
Research Interest: Neurosciences
Cell Type: Neurons
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
5µg
$80.00
25µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00