Animal-Free Recombinant Human NT-4
Catalog Number : AF-450-04
description
NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-4 is expressed in the prostate, thymus, placenta and skeletal muscle. NT-4 can signal through the LNGFR and trkB receptors and promotes the survival of peripheral sensory sympathetic neurons. Recombinant human NT-4 is a noncovalently linked homodimer, of two 14.0 kDa polypeptide monomers (260 total amino acid residues). Manufactured using all non-animal reagents.
Additional Information
Source: | E. Coli |
Purity: | Above 98% as determined by SDS-PAGE Analysis. |
Cross Reactivity: | NULL |
Biological Activity | Determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml. |
AA Sequence | GVSETAPAS RRGELAVCD AVSGWVTDR RTAVDLRGR EVEVLGEVP AAGGSPLRQ YFFETRCKA DNAEEGGPG AGGGGCRGV DRRHWVSEC KAKQSYVRA LTADAQGRV GWRWIRIDT ACVCTLLSR TGRA |
| Research Interest: | Stem Cell Research, Neurosciences, Metabolic Regulation and Diabetes |
|---|---|
| Cell Type: | Neurons |
| Application: | FA |
| Protein Cross Reactivity: | NULL |