Animal-Free Recombinant Human NT-4
Catalog Number : AF-450-04
description
NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-4 is expressed in the prostate, thymus, placenta and skeletal muscle. NT-4 can signal through the LNGFR and trkB receptors and promotes the survival of peripheral sensory sympathetic neurons. Recombinant human NT-4 is a noncovalently linked homodimer, of two 14.0 kDa polypeptide monomers (260 total amino acid residues). Manufactured using all non-animal reagents.
Additional Information
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Source:
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E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity:
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NULL
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Biological Activity
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Determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml.
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AA Sequence
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GVSETAPAS RRGELAVCD AVSGWVTDR RTAVDLRGR EVEVLGEVP AAGGSPLRQ YFFETRCKA DNAEEGGPG AGGGGCRGV DRRHWVSEC KAKQSYVRA LTADAQGRV GWRWIRIDT ACVCTLLSR TGRA
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| Research Interest: | Stem Cell Research, Neurosciences, Metabolic Regulation and Diabetes |
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| Cell Type: | Neurons |
| Application: | FA |
| Protein Cross Reactivity: | NULL |