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Animal-Free Recombinant Human β-NGF



Catalog Number : AF-450-01

Description

β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity. Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Chicken, Hamster, Mouse, Rat
 
Biological Activity
Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg
 
AA Sequence
SSSHPIFHR GEFSVCDSV SVWVGDKTT ATDIKGKEV MVLGEVNIN NSVFKQYFF ETKCRDPNP VDSGCRGID SKHWNSYCT TTHTFVKAL TMDGKQAAW RFIRIDTAC VCVLSRKAV RRA
Research Interest: Innate Immunity, Stem Cell Research, Angiogenesis, Neurosciences, Inflammation
Cell Type: B Cells, Neurons
Protein Cross Reactivity: Chicken, Hamster, Mouse, Rat

Availability: In stock

Size Price Qty
100µg
$215.00
250µg
$420.00
500µg
$720.00
1mg
$1,200.00