Recombinant Rat VEGF
Catalog Number : 400-31
description
VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothellial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase(flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant rat VEGF is a 38.5 kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.
Additional Information
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Source:
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E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity:
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Human
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Biological Activity
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Determined by the dose-dependent stimulation of the proliferation of Human umbilical vein endothelial cells (HUVEC). The expected ED50 is 4.0-8.0 ng/ml.
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AA Sequence
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MAPTTEGEQ KAHEVVKFM DVYQRSYCR PIETLVDIF QEYPDEIEY IFKPSCVPL MRCAGCCND EALECVPTS ESNVTMQIM RIKPHQSQH IGEMSFLQH SRCECRPKK DRTKPEKHC EPCSERRKH LFVQDPQTC KCSCKNTDS RCKARQLEL NERTCRCDK PRR
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| Research Interest: | Stem Cell Research, Cancer, Angiogenesis, Inflammation, Proliferation and Cell Cycle |
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| Cell Type: | Macrophage / Monocyte, Stem Cells |
| Application: | FA |
| Protein Cross Reactivity: | Human |