Recombinant Murine VEGF
Catalog Number : 450-32
description
VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant murine VEGF is a 39.0 kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.
Additional Information
Source: | E. Coli |
Purity: | Above 98% as determined by SDS-PAGE Analysis. |
Cross Reactivity: | Chicken, Human, Rabbit, Rat |
Biological Activity | Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-5.0 ng/ml. |
AA Sequence | MAPTTEGEQ KSHEVIKFM DVYQRSYCR PIETLVDIF QEYPDEIEY IFKPSCVPL MRCAGCCND EALECVPTS ESNITMQIM RIKPHQSQH IGEMSFLQH SRCECRPKK DRTKPEKHC EPCSERRKH LFVQDPQTC KCSCKNTDS RCKARQLEL NERTCRCDK PRR |
Research Interest: | Stem Cell Research, Cancer, Angiogenesis, Inflammation, Proliferation and Cell Cycle |
---|---|
Cell Type: | Macrophage / Monocyte, Stem Cells |
Application: | FA |
Protein Cross Reactivity: | Chicken, Human, Rabbit, Rat |