Recombinant Human VEGF-D
Catalog Number : 100-20D
VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant human VEGF-D is a 26.2 kDa non-disulfide linked homodimeric protein consisting of two 117 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.
Above 95% as determined by SDS-PAGE Analysis.
Measured by its ability to bind immobilized recombinant human Neuropilin-1 in an ELISA.
FAATFYDIE TLKVIDEEW QRTQCSPRE TCVEVASEL GKSTNTFFK PPCVNVFRC GGCCNEESL ICMNTSTSY ISKQLFEIS VPLTSVPEL VPVKVANHT GCKCLPTAP RHPYSIIRR
|Research Interest:||Cancer, Angiogenesis, Inflammation, Proliferation and Cell Cycle|
|Cell Type:||Endothelial Cells|
|Protein Cross Reactivity:||NULL|