Recombinant Murine TRAIL
Catalog Number : 315-19
TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic “death domain”, which activates the cell’s apoptotic machinery. Recombinant murine TRAIL is a 174 amino acid polypeptide (20.0 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL protein.
Above 95% as determined by SDS-PAGE Analysis.
Assay#1:Determined by the dose-dependent stimulation of MIP-2 production by mouse spleen cells using a concentration range of 10-100 ng/ml.
Assay#2:Measured by its ability to induce apoptosis in LN-18 cells
MRGGRPQKV AAHITGITR RSNSALIPI SKDGKTLGQ KIESWESSR KGHSFLNHV LFRNGELVI EQEGLYYIY SQTYFRFQE AEDASKMVS KDKVRTKQL VQYIYKYTS YPDPIVLMK SARNSCWSR DAEYGLYSI YQGGLFELK KNDRIFVSV TNEHLMDLD QEASFFGAF LIN
|Protein Cross Reactivity:||Human|