Recombinant Human TNF-α
Catalog Number : 300-01A
TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
Above 98% as determined by SDS-PAGE Analysis.
Cow, Monkey, Mouse, Rat, Sheep
The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
VRSSSRTPS DKPVAHVVA NPQAEGQLQ WLNRRANAL LANGVELRD NQLVVPSEG LYLIYSQVL FKGQGCPST HVLLTHTIS RIAVSYQTK VNLLSAIKS PCQRETPEG AEAKPWYEP IYLGGVFQL EKGDRLSAE INRPDYLDF AESGQVYFG IIAL
|Research Interest:||Innate Immunity, Adaptive Immunity, Stem Cell Research, Apoptosis, Cancer, Angiogenesis, Neurosciences, Inflammation, Metabolic Regulation and Diabetes|
|Cell Type:||B Cells, Macrophage / Monocyte, T Cells|
|Protein Cross Reactivity:||Cow, Monkey, Mouse, Rat, Sheep|