Recombinant Human TNF-β (E.coli-derived)

Grouped product items
SizePrice Qty
5µg
$80.00
20µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00
Catalog Number : 300-01B

description

TNF-β is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-β is produced by activated T and B lymphocytes, and has similar activities to TNF-α. Like TNF-α, TNF-β is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-β is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-β, which effectively anchors the TNF-β to the cell surface. TNF-β is cytotoxic to a wide range of tumor cells. Recombinant human TNF-β is a secreted 171 amino acid protein (18.6 kDa) which forms an active non-disulfide linked homotrimer structure in solution.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
Mouse
Biological Activity
The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin-D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
AA Sequence
MLPGVGLTP SAAQTARQH PKMHLAHST LKPAAHLIG DPSKQNSLL WRANTDRAF LQDGFSLSN NSLLVPTSG IYFVYSQVV FSGKAYSPK ATSSPLYLA HEVQLFSSQ YPFHVPLLS SQKMVYPGL QEPWLHSMY HGAAFQLTQ GDQLSTHTD GIPHLVLSP STVFFGAFA L
Research Interest:Stem Cell Research, Apoptosis, Immunology, Angiogenesis, Neurosciences
Cell Type:B Cells, T Cells
Application:FA
Protein Cross Reactivity:Mouse
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