Recombinant Human TACI (TNFRSF13B)

Grouped product items
Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$850.00
500µg
$3,120.00
1mg
$5,200.00
Catalog Number : 310-17

description

TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors; NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclear-factor of activated T cells). TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRIL-stimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor. Recombinant human TACI is a soluble 159 amino acid polypeptide (17.8 kDa) comprising the TNFR homologous cysteine rich extracellular domain of the TACI protein.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
NULL
Biological Activity
Determined by its ability to block human BAFF induced T2B cell survival using a concentration range of 1.0-3.0 µg/ml.
AA Sequence
SGLGRSRRG GRSRVDQEE RFPQGLWTG VAMRSCPEE QYWDPLLGT CMSCKTICN HQSQRTCAA FCRSLSCRK EQGKFYDHL LRDCISCAS ICGQHPKQC AYFCENKLR SPVNLPPEL RRQRSGEVE NNSDNSGRY QGLEHRGSE ASPALPGLK LSADQV
Research Interest: Adaptive Immunity, Cancer, Inflammation
Cell Type: B Cells, T Cells
Application: FA
Protein Cross Reactivity: NULL
© BioGems International, Inc. All rights reserved.