Recombinant Human sTRAIL Receptor-2
Catalog Number : 310-19
TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain", which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-2/DR5 is a 14.9 kDa protein (133 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.
Above 98% as determined by SDS-PAGE Analysis.
sTRAIL Rec 2 reduced the production of LPS-induced TNF by its ability to neutralize endogenous TRAIL in fresh human PBMC. In this assay, endogenous TRAIL is induced during a 24 hour exposure to LPS (10 ng/mL) but in the presence of sTRAIL Rec 2, TRAI
MESALITQQ DLAPQQRVA PQQKRSSPS EGLCPPGHH ISEDGRDCI SCKYGQDYS THWNDLLFC LRCTRCDSG EVELSPCTT TRNTVCQCE EGTFREEDS PEMCRKCRT GCPRGMVKV GDCTPWSDI ECVHKES
|Research Interest:||Apoptosis, Receptors|
|Protein Cross Reactivity:||NULL|