Recombinant Human sTRAIL Receptor-2

Grouped product items
Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00
Catalog Number : 310-19

description

TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain", which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-2/DR5 is a 14.9 kDa protein (133 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
NULL
Biological Activity
sTRAIL Rec 2 reduced the production of LPS-induced TNF by its ability to neutralize endogenous TRAIL in fresh human PBMC. In this assay, endogenous TRAIL is induced during a 24 hour exposure to LPS (10 ng/mL) but in the presence of sTRAIL Rec 2, TRAI
AA Sequence
MESALITQQ DLAPQQRVA PQQKRSSPS EGLCPPGHH ISEDGRDCI SCKYGQDYS THWNDLLFC LRCTRCDSG EVELSPCTT TRNTVCQCE EGTFREEDS PEMCRKCRT GCPRGMVKV GDCTPWSDI ECVHKES
Research Interest: Apoptosis, Receptors
Application: FA
Protein Cross Reactivity: NULL
© BioGems International, Inc. All rights reserved.