Recombinant Human sTRAIL Receptor-1
Catalog Number : 310-18
TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain, " which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7 kDa protein (215 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.
Above 98% as determined by SDS-PAGE Analysis.
Measured by its ability to inhibit apoptosis in LN-18 cells. The expected ED50 for this effect is 0.4 -0.5 µg/ml.
MSGTGAAAA TPSKVWGSS AGRIEPRGG GRGALPTSM GQHGPSARA RAGRAPGPR PAREASPRL RVHKTFKFV VVGVLLQVV PSSAATIKL HDQSIGTQQ WEHSPLGEL CPPGSHRSE RPGACNRCT EGVGYTNAS QQLFACLPC TACKSDEEE RSPCTTTRN TACQCKPGT FRNDNSAEM CRKCSTGCP RGMVKVKDC TPWSDIECV HKESGNGHN
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