Recombinant Human sTRAIL/Apo2L
Catalog Number : 310-04
TRAIL/Apo2L is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain", which activates the cell's apoptotic machinery. Recombinant human soluble TRAIL/Apo2L is a 168 amino acid polypeptide (19.6 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL/Apo2L protein.
Above 98% as determined by SDS-PAGE Analysis.
Assay#1:Determined by its ability to induce apoptotic cell death in TRAIL-sensitive U343MG cells. The expected ED50 for this effect is 1.0-3.0 ng/ml.
Assay#2:Measured by its abili
MRERGPQRV AAHITGTRG RSNTLSSPN SKNEKALGR KINSWESSR SGHSFLSNL HLRNGELVI HEKGFYYIY SQTYFRFQE EIKENTKND KQMVQYIYK YTSYPDPIL LMKSARNSC WSKDAEYGL YSIYQGGIF ELKENDRIF VSVTNEHLI DMDHEASFF GAFLVG
|Protein Cross Reactivity:||Mouse|