Recombinant Human sTNF Receptor Type II
Catalog Number : 310-12
TNFRII is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF-α but manifests a lower affinity to TNF-β. Signaling through this receptor regulates various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Soluble TNFRII is capable of inhibiting TNF-α induced activities by acting as a decoy receptor. Recombinant human sTNFRII is an 18.9 kDa protein (174 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFRII protein.
Above 98% as determined by SDS-PAGE Analysis.
Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of recombinant human TNF-α, is 0.125 µg/ml.
MAPEPGSTC RLREYYDQT AQMCCSKCS PGQHAKVFC TKTSDTVCD SCEDSTYTQ LWNWVPECL SCGSRCSSD QVETQACTR EQNRICTCR PGWYCALSK QEGCRLCAP LRKCRPGFG VARPGTETS DVVCKPCAP GTFSNTTSS TDICRPHQI CNVVAIPGN ASMDAVCTS TSP
|Research Interest:||Apoptosis, Neurosciences, Receptors, Inflammation, Proliferation and Cell Cycle|
|Cell Type:||Endothelial Cells|
|Protein Cross Reactivity:||Mouse|