Recombinant Human TGF-β1 (HEK 293 derived)
Catalog Number : 100-21
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Human TGF-β1 is a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond.
Above 98% as determined by SDS-PAGE Analysis.
Chicken, Cow, Dog, Frog, Monkey, Mouse, Pig, Rabbit, Rat
The ED50 was determined by TGF-beta1's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
ALDTNYCFS STEKNCCVR QLYIDFRKD LGWKWIHEP KGYHANFCL GPCPYIWSL DTQYSKVLA LYNQHNPGA SAAPCCVPQ ALEPLPIVY YVGRKPKVE QLSNMIVRS CKCS
|Research Interest:||Innate Immunity, Stem Cell Research, Apoptosis, Cancer, Angiogenesis, Inflammation, Proliferation and Cell Cycle|
|Cell Type:||T Cells, T Regulatory Cells|
|Protein Cross Reactivity:||Chicken, Cow, Dog, Frog, Monkey, Mouse, Pig, Rabbit, Rat|