Recombinant Murine PDGF-AA
Catalog Number : 315-17
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-AA is a 28.7 kDa disulfide-linked homodimer of two A chains (250 total amino acids).
Above 98% as determined by SDS-PAGE Analysis.
Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 8-10 ng/ml.
MSIEEAVPA VCKTRTVIY EIPRSQVDP TSANFLIWP PCVEVKRCT GCCNTSSVK CQPSRVHHR SVKVAKVEY VRKKPKLKE VQVRLEEHL ECACATSNL NPDHREEET GRRRESGKN RKRKRLKPT
|Research Interest:||Stem Cell Research, Immunology, Cancer, Angiogenesis, Neurosciences, Bone Biology|
|Cell Type:||Stem Cells, Neurons|
|Protein Cross Reactivity:||NULL|