Recombinant Human PDGF-AA
Catalog Number : 100-13A
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids).
Above 98% as determined by SDS-PAGE Analysis.
Dog, Monkey, Mouse, Rat
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by Balb/c 3T3 cells is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
SIEEAVPAV CKTRTVIYE IPRSQVDPT SANFLIWPP CVEVKRCTG CCNTSSVKC QPSRVHHRS VKVAKVEYV RKKPKLKEV QVRLEEHLE CACATTSLN PDYREEDTG RPRESGKKR KRKRLKPT
|Research Interest:||Stem Cell Research, Immunology, Cancer, Angiogenesis, Neurosciences, Bone Biology|
|Protein Cross Reactivity:||Dog, Monkey, Mouse, Rat|