Animal-Free Recombinant Human PDGF-AA

Grouped product items
Size Price Qty
10µg
$215.00
100µg
$860.00
500µg
$2,580.00
1mg
$4,300.00
Catalog Number : AF-100-13A

description

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids). Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
Dog, Monkey, Mouse, Rat
Biological Activity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by Balb/c 3T3 cells is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
AA Sequence
SIEEAVPAV CKTRTVIYE IPRSQVDPT SANFLIWPP CVEVKRCTG CCNTSSVKC QPSRVHHRS VKVAKVEYV RKKPKLKEV QVRLEEHLE CACATTSLN PDYREEDTG RPRESGKKR KRKRLKPT
Research Interest: Stem Cell Research, Immunology, Cancer, Angiogenesis, Neurosciences, Bone Biology
Application: FA
Protein Cross Reactivity: Dog, Monkey, Mouse, Rat
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