Recombinant Rat IL-6
Catalog Number : 400-06
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant rat IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is < 0.01 ng/ml, corresponding to a specific activity of > 1 x 108 units/mg.
MFPTSQVRR GDFTEDTTH NRPVYTTSQ VGGLITYVL REILEMRKE LCNGNSDCM NSDDALSEN NLKLPEIQR NDGCFQTGY NQEICLLKI CSGLLEFRF YLEFVKNNL QDNKKDKAR VIQSNTETL VHIFKQEIK DSYKIVLPT PTSNALLME KLESQKEWL RTKTIQLIL KALEEFLKV TMRSTRQT
|Research Interest:||Innate Immunity, Adaptive Immunity, Stem Cell Research, Cancer, Angiogenesis, Neurosciences, Inflammation, Metabolic Regulation and Diabetes|
|Cell Type:||B Cells, Macrophage / Monocyte, T Cells, Stem Cells, Endothelial Cells|
|Protein Cross Reactivity:||Mouse|