Recombinant Rat IL-4
Catalog Number : 400-04
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant rat IL-4 is a 14.0 kDa globular protein containing 126 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Tested by its ability to suppress LPS-induced TNF-α and MIP-2 production in mouse splenocytes.
MHGCNDSPL REIINTLNQ VTEKGTPCT EMFVPDVLT ATRNTTENE LICRASRVL RKFYFPRDV PPCLKNKSG VLGELRKLC RGVSGLNSL RSCTVNEST LTTLKDFLE SLKSILRGK YLQSCTSMS
|Research Interest:||Innate Immunity, Adaptive Immunity, Stem Cell Research, Apoptosis, Immunology, Cancer, Inflammation, Proliferation and Cell Cycle|
|Cell Type:||T Cells|
|Protein Cross Reactivity:||Mouse|