Recombinant Rat IL-3β
Catalog Number : 400-03
IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant rat IL-3β is a 16.3 kDa globular protein containing 144 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
The ED50 was determined by the dose-dependent stimulation of the proliferation of thymidine uptake by murine MC-9 cells is < 10 ng/ml, corresponding to a specific activity of >1.0 x 1
MISDRGSDA HHLLRTLDC RTIALEILV KLPYPQVSG LNNSDDKAN LRNSTLRRV NLDEFLKSQ EEFDSQDTT DIKSKLQKL KCCIPAAAS DSVLPGVYN KDLDDFKKK LRFYVIHLK DLQPVSVSR PPQPTSSSD NFRPMTVEC
|Research Interest:||Innate Immunity, Adaptive Immunity, Stem Cell Research, Immunology, Cancer, Proliferation and Cell Cycle|
|Cell Type:||Macrophage / Monocyte, T Cells|
|Protein Cross Reactivity:||Mouse|