Recombinant Rat IL-1β
Catalog Number : 400-01B
description
IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant rat IL-1β is a 17.4 kDa protein containing 153 amino acid residues.
Additional Information
|
Source:
|
E. Coli
|
|
Purity:
|
Above 98% as determined by SDS-PAGE Analysis.
|
|
Cross Reactivity:
|
Mouse
|
|
Biological Activity
|
The ED50 was determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
|
|
AA Sequence
|
MVPIRQLHC RLRDEQQKC LVLSDPCEL KALHLNGQN ISQQVVFSM SFVQGETSN DKIPVALGL KGLNLYLSC VMKDGTPTL QLESVDPKQ YPKKKMEKR FVFNKIEVK TKVEFESAQ FPNWYISTS QAEHRPVFL GNSNGRDIV DFTMEPVSS
|
| Research Interest: | Innate Immunity, Stem Cell Research, Immunology, Cancer, Angiogenesis, Neurosciences, Inflammation |
|---|---|
| Cell Type: | B Cells, Macrophage / Monocyte |
| Application: | FA |
| Protein Cross Reactivity: | Mouse |