Recombinant Rat IL-13 (113 a.a.)
Catalog Number : 400-16L
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant rat IL-13 is a 12.3 kDa protein consisting of 113 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
The ED50 was determined by the dose-dependent proliferation of TF-1 cells is < 5.0 ng/ml, corresponding to a specific activity of > 2 x 105 units/mg.
TPGPVRRST SPPVALREL IEELSNITQ DQKTSLCNS SIVWSVDLT AGGFCAALE SLTNISSCN AIHRTQRIL NGLCNQKAS DVASSPPDT KIEVAQFIS KLLNYSKQL FRYGH
|Research Interest:||Innate Immunity, Adaptive Immunity, Stem Cell Research, Immunology, Cancer, Inflammation|
|Cell Type:||Macrophage / Monocyte, T Cells|
|Protein Cross Reactivity:||Human|