Recombinant Murine IL-3
Catalog Number : 213-13
IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
The ED50 as determined by the dose-dependent stimulation of the proliferation of murine NFS-60 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
MDTHRLTRT LNCSSIVKE IIGKLPEPE LKTDDEGPS LRNKSFRRV NLSKFVESQ GEVDPEDRY VIKSNLQKL NCCLPTSAN DSALPGVFI RDLDDFRKK LRFYMVHLN DLETVLTSR PPQPASGSV SPNRGTVEC
|Research Interest:||Innate Immunity, Adaptive Immunity, Stem Cell Research, Cancer, Proliferation and Cell Cycle|
|Cell Type:||Macrophage / Monocyte, T Cells, Stem Cells|
|Protein Cross Reactivity:||Gerbil, Rat|