Recombinant Murine IL-1β
Catalog Number : 211-11B
description
IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant murine IL-1β is a 17.5 kDa protein containing 153 amino acid residues.
Additional Information
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Source:
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E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity:
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Human, Monkey, Pig, Rat, Mouse + Chicken
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Biological Activity
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The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.002 ng/ml, corresponding to a specific activity of ≥ 5 x 108 units/mg.
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AA Sequence
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MVPIRQLHY RLRDEQQKS LVLSDPYEL KALHLNGQN INQQVIFSM SFVQGEPSN DKIPVALGL KGKNLYLSC VMKDGTPTL QLESVDPKQ YPKKKMEKR FVFNKIEVK SKVEFESAE FPNWYISTS QAEHKPVFL GNNSGQDII DFTMESVSS
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| Research Interest: | Innate Immunity, Stem Cell Research, Immunology, Cancer, Angiogenesis, Neurosciences, Inflammation, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes |
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| Cell Type: | B Cells, Macrophage / Monocyte |
| Application: | FA |
| Protein Cross Reactivity: | Human, Monkey, Pig, Rat, Mouse + Chicken |