Recombinant Murine IL-1β
Catalog Number : 211-11B
IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant murine IL-1β is a 17.5 kDa protein containing 153 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Human, Monkey, Pig, Rat, Mouse + Chicken
The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.002 ng/ml, corresponding to a specific activity of ≥ 5 x 108 units/mg.
MVPIRQLHY RLRDEQQKS LVLSDPYEL KALHLNGQN INQQVIFSM SFVQGEPSN DKIPVALGL KGKNLYLSC VMKDGTPTL QLESVDPKQ YPKKKMEKR FVFNKIEVK SKVEFESAE FPNWYISTS QAEHKPVFL GNNSGQDII DFTMESVSS
|Research Interest:||Innate Immunity, Stem Cell Research, Immunology, Cancer, Angiogenesis, Neurosciences, Inflammation, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes|
|Cell Type:||B Cells, Macrophage / Monocyte|
|Protein Cross Reactivity:||Human, Monkey, Pig, Rat, Mouse + Chicken|