Recombinant Murine IL -22
Catalog Number : 210-22
IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant murine IL-22 is a 33.4 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.
Above 98% as determined by SDS-PAGE Analysis.
Assay#1: Determined by its ability to activate STAT following receptor ligand interaction.
Assay#2: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The expected ED
MLPVNTRCK LEVSNFQQP YIVNRTFML AKEASLADN NTDVRLIGE KLFRGVSAK DQCYLMKQV LNFTLEDVL LPQSDRFQP YMQEVVPFL TKLSNQLSS CHISGDDQN IQKNVRRLK ETVKKLGES GEIKAIGEL DLLFMSLRN ACV
|Research Interest:||Adaptive Immunity|
|Cell Type:||T Cells|
|Protein Cross Reactivity:||NULL|