Recombinant Murine IL-17 (IL-17A)
Catalog Number : 210-17
The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains.
Above 98% as determined by SDS-PAGE Analysis.
Measured by its ability to induce IL-6 production by NIH 3T3 cells.
AAIIPQSSA CPNTEAKDF LQNVKVNLK VFNSLGAKV SSRRPSDYL NRSTSPWTL HRNEDPDRY PSVIWEAQC RHQRCVNAE GKLDHHMNS VLIQQEILV LKREPESCP FTFRVEKML VGVGCTCVA SIVRQAA
|Research Interest:||Adaptive Immunity, Immunology, Angiogenesis, Inflammation|
|Cell Type:||T Cells|
|Protein Cross Reactivity:||Rat|