Recombinant Murine IL-10
Catalog Number : 210-10
IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant murine IL-10 is an 18.7 kDa protein of 161 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
PeproTech's murine IL-10 is fully biologically active as measured by the dose-dependent co-stimulation (with IL-4) of the proliferation of murine MC/9 cells. The ED50 was found to be < 2 ng/ml, corresponding to a specific activity of > 5
MSRGQYSRE DNNCTHFPV GQSHMLLEL RTAFSQVKT FFQTKDQLD NILLTDSLM QDFKGYLGC QALSEMIQF YLVEVMPQA EKHGPEIKE HLNSLGQKL KTLRMRLRR CHRFLPCEN KSKAVEQVK SDFNKLEDQ GVYKAMNEF DIFINCIEA YMMIKMKS
|Research Interest:||Innate Immunity, Stem Cell Research, Immunology, Cancer, Neurosciences, Inflammation|
|Cell Type:||B Cells, Macrophage / Monocyte, T Cells, T Regulatory Cells|
|Protein Cross Reactivity:||Human|