Recombinant Human IL-4
Catalog Number : 200-04
description
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.
Additional Information
Source: | E. Coli |
Purity: | Above 98% as determined by SDS-PAGE Analysis. |
Cross Reactivity: | NULL |
Biological Activity | The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg. |
AA Sequence | MHKCDITLQ EIIKTLNSL TEQKTLCTE LTVTDIFAA SKNTTEKET FCRAATVLR QFYSHHEKD TRCLGATAQ QFHRHKQLI RFLKRLDRN LWGLAGLNS CPVKEANQS TLENFLERL KTIMREKYS KCSS |
| Research Interest: | Innate Immunity, Adaptive Immunity, Stem Cell Research, Apoptosis, Immunology, Cancer, Inflammation, Proliferation and Cell Cycle |
|---|---|
| Cell Type: | T Cells |
| Application: | FA |
| Protein Cross Reactivity: | NULL |