Recombinant Human IL-36RA
Catalog Number : 200-36RA
The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kappaB signaling induced by either IL-36α, -β or -γ by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant human IL-36RA is an E. coli derived 17 kDa protein containing 154 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Measured by its ability to inhibit IL-36γ induced IL-6 production by human PBMCs.
VLSGALCFR MKDSALKVL YLHNNQLLA GGLHAEKVI KGEEISVVP NRALDASLS PVILGVQGG SQCLSCGTE KGPILKLEP VNIMELYLG AKESKSFTF YRRDMGLTS SFESAAYPG WFLCTSPEA DQPVRLTQI PEDPAWDAP ITDFYFQQC D
|Research Interest:||Innate Immunity, Immunology, Cancer, Neurosciences, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes|
|Cell Type:||Dendritic Cells|
|Protein Cross Reactivity:||NULL|