Recombinant Human IL-36β (IL-1F8)
Catalog Number : 200-36B
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36β is a 17.3 kDa protein containing 154 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Measured by its ability to induce IL-8 production by human PBMCs.
MREAAPKSY AIRDSRQMV WVLSGNSLI AAPLSRSIK PVTLHLIAC RDTEFSDKE KGNMVYLGI KGKDLCLFC AEIQGKPTL QLKEKNIMD LYVEKKAQK PFLFFHNKE GSTSVFQSV SYPGWFIAT STTSGQPIF LTKERGITN NTNFYLDSV E
|Research Interest:||Innate Immunity, Immunology, Cancer, Neurosciences, Inflammation, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes|
|Cell Type:||Dendritic Cells|
|Protein Cross Reactivity:||NULL|