Recombinant Human IL-34
Catalog Number : 200-34
description
IL-34 is a homodimeric cytokine that is expressed in a range of tissues including spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1 stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. Recombinant human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag.
Additional Information
Source: | HEK293 cells |
Purity: | Above 95% as determined by SDS-PAGE Analysis. |
Cross Reactivity: | NULL |
Biological Activity | Measured by its ability to induce secretion of MCP-1 from PBMCs. |
AA Sequence | NEPLEMWPL TQNEECTVT GFLRDKLQY RSRLQYMKH YFPINYKIS VPYEGVFRI ANVTRLQRA QVSERELRY LWVLVSLSA TESVQDVLL EGHPSWKYL QEVETLLLN VQQGLTDVE VSPKVESVL SLLNAPGPN LKLVRPKAL LDNCFRVME LLYCSCCKQ SSVLNWQDC EVPSPQSCS PEPSLQYAA TQLYPPPPW SPSSPPHST GSVRPVRAQ GEGLLPHHH HHHHH |
| Research Interest: | Innate Immunity, Immunology, Cancer, Neurosciences, Inflammation, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes |
|---|---|
| Cell Type: | Dendritic Cells |
| Application: | FA |
| Protein Cross Reactivity: | NULL |