Recombinant Human IL-34
Catalog Number : 200-34
IL-34 is a homodimeric cytokine that is expressed in a range of tissues including spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1 stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. Recombinant human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag.
Above 95% as determined by SDS-PAGE Analysis.
Measured by its ability to induce secretion of MCP-1 from PBMCs.
NEPLEMWPL TQNEECTVT GFLRDKLQY RSRLQYMKH YFPINYKIS VPYEGVFRI ANVTRLQRA QVSERELRY LWVLVSLSA TESVQDVLL EGHPSWKYL QEVETLLLN VQQGLTDVE VSPKVESVL SLLNAPGPN LKLVRPKAL LDNCFRVME LLYCSCCKQ SSVLNWQDC EVPSPQSCS PEPSLQYAA TQLYPPPPW SPSSPPHST GSVRPVRAQ GEGLLPHHH HHHHH
|Research Interest:||Innate Immunity, Immunology, Cancer, Neurosciences, Inflammation, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes|
|Cell Type:||Dendritic Cells|
|Protein Cross Reactivity:||NULL|