Recombinant Human IL-31
Catalog Number : 200-31
Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant IL-31 is a 15.8 kDa protein containing 141 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Measured by its ability to induce STAT3 activation in human U87 cells.
SHTLPVRLL RPSDDVQKI VEELQSLSK MLLKDVEEE KGVLVSQNY TLPCLSPDA QPPNNIHSP AIRAYLKTI RQLDNKSVI DEIIEHLDK LIFQDAPET NISVPTDTH ECKRFILTI SQQFSECMD LALKSLTSG AQQATT
|Research Interest:||Innate Immunity, Adaptive Immunity, Inflammation|
|Cell Type:||T Cells|
|Protein Cross Reactivity:||NULL|