Recombinant Human IL -24
Catalog Number : 200-35
IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. It is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include the induction of differentiation and apoptosis, and the suppression of angiogenesis and cell proliferation. Recombinant human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag.
Above 95% as determined by SDS-PAGE Analysis.
Testing in progress.
QEFHFGPCQ VKGVVPQKL WEAFWAVKD TMQAQDNIT SARLLQQEV LQNVSDAES CYLVHTLLE FYLKTVFKN YHNRTVEVR TLKSFSTLA NNFVLIVSQ LQPSQENEM FSIRDSAHR RFLLFRRAF KQLDVEAAL TKALGEVDI LLTWMQKFY KLHHHHHH
|Research Interest:||Apoptosis, Cancer|
|Cell Type:||B Cells, Macrophage / Monocyte|
|Protein Cross Reactivity:||NULL|