Recombinant Human IL -23
Catalog Number : 200-23
IL-23 is a proinflammatory heterodimeric protein composed of two subunits, a unique p19 subunit and a p40 subunit, which is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rβ2. IL-23 has been shown to enhance proliferation of memory T cells. It also stimulates the production of IFN-γ in NK cells, induces IL-17 production, and drives Th17 mediated responses. Recombinant IL-23 is a 53.5 kDa heterodimeric protein consisting of two subunits, p19 (170 amino acids) and p40 (306 amino acids).*Manufactured using BTI-Tn-5B1-4 cells under license from the Boyce Thompson Institute for Plant Research, Inc.
(BTI-Tn-5B1-4) Hi-5 Insect cells*
Above 95% as determined by SDS-PAGE Analysis.
Measured by its ability to induce IL-17 secretion by mouse splenocytes.
RAVPGGSSP AWTQCQQLS QKLCTLAWS AHPLVGHMD LREEGDEET TNDVPHIQC GDGCDPQGL RDNSQFCLQ RIHQGLIFY EKLLGSDIF TGEPSLLPD SPVGQLHAS LLGLSQLLQ PEGHHWETQ QIPSLSPSQ PWQRLLLRF KILRSLQAF VAVAARVFA HGAATLSPI WELKKDVYV VELDWYPDA PGEMVVLTC DTPEEDGIT WTLDQSSEV LGSGKTLTI QVKEFGDAG QYTCHKGGE VLSHSLLLL HKKEDGIWS TDILKDQKE PKNKTFLRC EAKNYSGRF TCWWLTTIS TDLTFSVKS SRGSSDPQG VTCGAATLS AERVRGDNK EYEYSVECQ EDSACPAAE ESLPIEVMV DAVHKLKYE NYTSSFFIR DIIKPDPPK NLQLKPLKN SRQVEVSWE YPDTWSTPH SYFSLTFCV QVQGKSKRE KKDRVFTDK TSATVICRK NASISVRAQ DRYYSSSWS EWASVPCS
|Research Interest:||Innate Immunity, Immunology, Cancer, Inflammation|
|Cell Type:||Macrophage / Monocyte, T Cells, Dendritic Cells|
|Protein Cross Reactivity:||Mouse|