Recombinant Human IL-20
Catalog Number : 200-20
IL-20 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL-20 signals through a receptor system composed of type I IL-20R-α and type II IL-20R-β. Over-expression of IL-20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease. Recombinant human IL-20 is a 35.2 kDa homodimeric protein consisting of two 153 amino acid polypeptide chains.
Above 98% as determined by SDS-PAGE Analysis.
Determined by its ability to activate STAT following receptor ligand interaction.
MLKTLNLGS CVIATNLQE IRNGFSEIR GSVQAKDGN IDIRILRRT ESLQDTKPA NRCCLLRHL LRLYLDRVF KNYQTPDHY TLRKISSLA NSFLTIKKD LRLCHAHMT CHCGEEAMK KYSQILSHF EKLEPQAAV VKALGELDI LLQWMEETE
|Research Interest:||Stem Cell Research, Immunology, Inflammation, Proliferation and Cell Cycle|
|Protein Cross Reactivity:||NULL|