Recombinant Human IL-1Ra
Catalog Number : 200-01RA
Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL-1α and IL-1β by competitively blocking binding to their type I and type II receptors. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant human IL-1Ra is a 17.2 kDa protein consisting of 153 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Frog, Mouse, Rat
Determined by its ability to inhibit the IL-1α stimulation of murine D10S cell. The expected ED50 is 20-40 ng/ml in the presence of 50 pg/ml of IL-1α.
MRPSGRKSS KMQAFRIWD VNQKTFYLR NNQLVAGYL QGPNVNLEE KIDVVPIEP HALFLGIHG GKMCLSCVK SGDETRLQL EAVNITDLS ENRKQDKRF AFIRSDSGP TTSFESAAC PGWFLCTAM EADQPVSLT NMPDEGVMV TKFYFQEDE
|Research Interest:||Innate Immunity, Neurosciences, Inflammation, Metabolic Regulation and Diabetes|
|Cell Type:||Macrophage / Monocyte|
|Protein Cross Reactivity:||Frog, Mouse, Rat|