Recombinant Human IL-17 (IL-17A)
Catalog Number : 200-17
The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.3 kDa disulfide-linked homodimer of two 137 amino acid polypeptide chains.
Above 98% as determined by SDS-PAGE Analysis.
Assay #1: The ED50 as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/ml.
Assay #2: Measured by its ability to
MIVKAGITI PRNPGCPNS EDKNFPRTV MVNLNIHNR NTNTNPKRS SDYYNRSTS PWNLHRNED PERYPSVIW EAKCRHLGC INADGNVDY HMNSVPIQQ EILVLRREP PHCPNSFRL EKILVSVGC TCVTPIVHH VA
|Research Interest:||Adaptive Immunity, Immunology, Angiogenesis, Inflammation|
|Cell Type:||T Cells, T Regulatory Cells|
|Protein Cross Reactivity:||Mouse|