Recombinant Human IL-16 (130 a.a.)
Catalog Number : 200-16
IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 13.5 kDa protein consisting of 130 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Human + Mouse
Determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 1.0-100.0 ng/ml.
MPDLNSSTD SAASASAAS DVSVESTAE ATVCTVTLE KMSAGLGFS LEGGKGSLH GDKPLTINR IFKGAASEQ SETVQPGDE ILQLGGTAM QGLTRFEAW NIIKALPDG PVTIVIRRK SLQSKETTA AGDS
|Research Interest:||Adaptive Immunity, Apoptosis, Immunology, Inflammation|
|Cell Type:||Macrophage / Monocyte, T Cells|
|Protein Cross Reactivity:||Human + Mouse|