Recombinant Human IL-13 Variant
Catalog Number : 200-13A
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13.The genetic variant, termed human IL-13 analog, is a mature 114 amino acid protein with a substitution of Q for R at position 112.
Above 98% as determined by SDS-PAGE Analysis.
This IL-13 analog shows a two fold increase, relative to wild type IL-13, in bioactivity as measured by the in-vitro dose dependent activation of STAT6 and IL-13 dependent gene induction in transfected A201.1 cells. This analog has also been show
MSPGPVPPS TALRELIEE LVNITQNQK APLCNGSMV WSINLTAGM YCAALESLI NVSGCSAIE KTQRMLSGF CPHKVSAGQ FSSLHVRDT KIEVAQFVK DLLLHLKKL FREGQFN
|Research Interest:||Innate Immunity, Adaptive Immunity, Stem Cell Research, Immunology, Cancer, Inflammation|
|Cell Type:||Macrophage / Monocyte, T Cells|
|Protein Cross Reactivity:||Mouse|