Recombinant Human IL-1α
Catalog Number : 200-01A
IL-1α is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1α is an 18.0 kDa protein containing 159 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Cow, Monkey, Mouse
The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.001 ng/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg.
SAPFSFLSN VKYNFMRII KYEFILNDA LNQSIIRAN DQYLTAAAL HNLDEAVKF DMGAYKSSK DDAKITVIL RISKTQLYV TAQDEDQPV LLKEMPEIP KTITGSETN LLFFWETHG TKNYFTSVA HPNLFIATK QDYWVCLAG GPPSITDFQ ILENQA
|Research Interest:||Innate Immunity, Adaptive Immunity, Stem Cell Research, Immunology, Cancer, Neurosciences, Inflammation, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes|
|Cell Type:||B Cells, Macrophage / Monocyte|
|Protein Cross Reactivity:||Cow, Monkey, Mouse|