Animal-Free Recombinant Human IL-9
IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erthroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin's disease. Whereas murine IL-9 can function on human cells, human IL-9 is inactive on mouse cells. Recombinant human IL-9 is a 14.0 kDa protein of 127 amino acid residues including 10 cysteine residues which are fully conserved between the human murine proteins. Manufactured using all non-animal reagents.
Above 98% as determined by SDS-PAGE Analysis.
The ED50 as determined by the dose-dependent proliferation of human M07e cells was ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
MQGCPTLAG ILDINFLIN KMQEDPASK CHCSANVTS CLCLGIPSD NCTRPCFSE RLSQMTNTT MQTRYPLIF SRVKKSVEV LKNNKCPYF SCEQPCNQT TAGNALTFL KSLLEIFQK EKMRGMRGK I
|Research Interest:||Adaptive Immunity, Cancer, Proliferation and Cell Cycle|
|Cell Type:||T Cells|
|Protein Cross Reactivity:||NULL|