Animal-Free Recombinant Human IL-36γ (IL-1F9)
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues. Manufactured using all non-animal reagents.
Above 95% as determined by SDS-PAGE Analysis.
Measured by its ability to induce IL-8 production by human PBMCs.
SMCKPITGT INDLNQQVW TLQGQNLVA VPRSDSVTP VTVAVITCK YPEALEQGR GDPIYLGIQ NPEMCLYCE KVGEQPTLQ LKEQKIMDL YGQPEPVKP FLFYRAKTG RTSTLESVA FPDWFIASS KRDQPIILT SELGKSYNT AFELNIND
|Research Interest:||Innate Immunity, Immunology, Cancer, Neurosciences, Inflammation, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes|
|Cell Type:||Dendritic Cells|
|Protein Cross Reactivity:||NULL|